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Inventi Impact: Genetics

Articles

  • Inventi:hgt/25084/18
    Genetic Variants in CSMD1 Gene Are Associated with Cognitive Performance in Normal Elderly\nPopulation
    01-Jan-1970 Research 2018 : April - June
    Vadim Stepanov, Andrey Marusin, Kseniya Vagaitseva, Anna Bocharova, Oksana Makeeva

    Recently, genetic markers rs10503253 and rs2616984 in the CUB and Sushi multiple domains-1 (CSMD1) gene have been reported\nto be associated with schizophrenia and cognitive functions in genome-wide association studies. We examined the associations\nof the above SNPs with cognitive performance evaluated by the Montreal Cognitive Assessment (MoCA) tool in a cohort of the\nnormal elderly fromthe Russian population. Significant association of rs2616984 genotypes with theMoCA scores was found using\nnonparametric analysis. No association of rs10503253 with MoCA scores was observed using both parametric and nonparametric\nstatistics. Significant combined effect of two-locus CSMD1 genotypes onMoCA scores was demonstrated by median test. Allele ââ?¬Å?Aââ?¬Â\nand genotype ââ?¬Å?AAââ?¬Â of rs2616984 were significantly associated with the lower MoCA scores in comparison of 1st and 4th quartiles\nofMoCA total score distribution.The results suggest that genetic variants in CSMD1 gene are likely a part of genetic component of\ncognitive performance in the elderly.

    How to Cite this Article
    CC Compliant Citation: Vadim Stepanov, Andrey Marusin, Kseniya\nVagaitseva, Anna Bocharova, and Oksana Makeeva, â??Genetic\nVariants in CSMD1 Gene Are Associated with Cognitive\nPerformance in Normal Elderly Population,â? Genetics Research\nInternational, vol. 2017, Article ID 6293826, 5 pages, 2017.\ndoi:10.1155/2017/6293826, https://creativecommons.org/\nlicenses/by/4.0/.
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